MOLECULAR DOCKING STUDIES ON THIADIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Objective: In the present study, a novel series of 1, 3, 4-thiadiazole derivatives were docked against the mycobacterium tuberculosis protein kinase G. 1, 3, 4–thiadiazole derivatives with a modified primary amine group at 5th position were used for docking studies. Methods: The three-dimensional structure of the protein was obtained from PDB, and its active sites were predicted. The structures of all the compounds were drawn using chemdraw software version 8.0. The docking studies were done by using schrödinger software against the enzyme protein kinase G. Totally eighteen compounds was synthesized based on glide score Results: In this Docking study the thiadiazole analogues were showing good binding energy. The amino acids residues GLU588, SER412, GLY410 and GLU 628 in the kinase domain active site form hydrogen bonds with the ligand. Conclusion: The compounds D34, D16, D7, D25, D15, and D27 showed better interaction with protein kinase G (pknG) more than the other drug molecule

Social Thoughts in Ambai's Short Stories

Ambai a Tamil Nadu woman writer who has highlighted the feminist voice for the emancipation of women in society and their strong personality development through her writings on the history of modern Tamil literature, has created in her short stories an understanding of the existence, challenges and place of women in society and her place in the social platform with a keen interest in her life. She has written about the problem of dowry in the social sphere, unrestrained male-female friendships, and women's sexual problems. Predictions about women-dependent fathers, husbands, brothers, companionship are also present in the short stories of the various instances of human relationship persistence. He is also a prolific writer of feminist issues. Who was supportive of the female class. The narrative that emerges in his stories has shaped each narrative to suit each period. Depicts the problems faced by women in the positions of mother, daughter, wife etc. where the woman is placed second. There have also been reports of sexual violence against women and young girls. The purpose of this review article is to express social thought through her works on the notion that women suffer in society because of their ‘virginity’ and the idea that women should be left out of traditional thinking and build a new world for themselves

EFFECT OF CURCUMA LONGA EXTRACT ON BIOFILM FORMATION BY STREPTOCOCCUS MUTANS

Objective: To find the effect of Curcuma longa extract on biofilm formation by Streptococcus mutans.Methods: The organism S. mutans was isolated from saliva sample using special media (Mutans - sanguis agar) and maintained in tryptone soya agar at 4°C in Department of Microbiology, Saveetha Dental College and Hospitals.Results: From the study, we infer that 78.35% of inhibition of the biofilm formation is seen with 100 ug of curcumin extract. From the result, it is evident that curcumin has a very good inhibitory effect on S. mutans growth.Conclusion: The study concludes the inhibitory action of curcumin on S. mutans by preventing biofilm formation

IHWC: intelligent hidden web crawler for harvesting data in urban domains

Due to the massive size of the hidden web, searching, retrieving and mining rich and high-quality data can be a daunting task. Moreover, with the presence of forms, data cannot be accessed easily. Forms are dynamic, heterogeneous and spread over trillions of web pages. Significant efforts have addressed the problem of tapping into the hidden web to integrate and mine rich data. Effective techniques, as well as application in special cases, are required to be explored to achieve an effective harvest rate. One such special area is atmospheric science, where hidden web crawling is least implemented, and crawler is required to crawl through the huge web to narrow down the search to specific data. In this study, an intelligent hidden web crawler for harvesting data in urban domains (IHWC) is implemented to address the relative problems such as classification of domains, prevention of exhaustive searching, and prioritizing the URLs. The crawler also performs well in curating pollution-related data. The crawler targets the relevant web pages and discards the irrelevant by implementing rejection rules. To achieve more accurate results for a focused crawl, ICHW crawls the websites on priority for a given topic. The crawler has fulfilled the dual objective of developing an effective hidden web crawler that can focus on diverse domains and to check its integration in searching pollution data in smart cities. One of the objectives of smart cities is to reduce pollution. Resultant crawled data can be used for finding the reason for pollution. The crawler can help the user to search the level of pollution in a specific area. The harvest rate of the crawler is compared with pioneer existing work. With an increase in the size of a dataset, the presented crawler can add significant value to emission accuracy. Our results are demonstrating the accuracy and harvest rate of the proposed framework, and it efficiently collect hidden web interfaces from large-scale sites and achieve higher rates than other crawlers

Environmental Hazards And Its Impact On Human Health

This paper provides the insight view about the environmental hazards and its impact on human health. Environmental hazards means every type of disorder that occur in the environment .Hazards can present themselves to us in various media e.g. air, water. The influence they can exert on our health is very complex and may be modulated by our genetic makeup, psychological factors and by our perceptions of the risks that they present. Every year thousands of deaths are reported because of environmental hazards. Environmental hazards can affect a particular organ or body system, directly damaging it or leading to further complications. In this paper we discuss about various hazards such as physical hazards (electromagnetic radiation and ionizing radiation),chemical hazards (combustion of coal, petroleum), biological hazards (contamination of water) and psychosocial hazards (stress).And also various types of pollution caused by the environmental hazards which results in various health problems such as liver damage, chronic headaches, mental retardation or damage to reproductive organs. These hazards place extra stress on our bodies

केंद्रीय समुद्री मात्स्यिकी अनुसंधान संस्थान का मंगलूर अनुसंधान केंद्र

केंद्रीय समुद्री मात्स्यिकी अनुसंधान संस्थान का मंगलूर अनुसंधान केंद्

Unusual catch rates of cuttlefish in a multiday trawler

Cuttlefish is one of the commercially important group of cephalopods caught by multi-night trawlers along the coast of Karnataka. The catch rate of cuttlefish in multiday trawlers varies from <5 kg/haul during December-April period to 50-300 kg/haul during the peak fishing season in August- September

Comparing the diagnostic accuracy of ct and USG in the diagnosis of acute appendicitis.

AIM OF THE STUDY: 1. The Aim of the study was to evaluate the accuracy of CT and USG in the diagnosis of acute appendicitis in patients who are taken for appendectomy on clinical basis. 2. To calculate the sensitivity, specificity positive predictive and negative predictive value of CT and USG. METHODOLOGY: Patients who were admitted in the surgical emergency ward with clinical findings and symptoms suspected of appendicitis .A total study sample of 100 was selected USG PROTOCOL: A routine USG was done in SONOSCAPE machine for the upper abdomen and pelvis using a 3-5–MHz convex transducer to rule out alternative abnormalities related to solid organs and to rule out free fluid.Then graded compression and colour Doppler sonography of the right lower quadrant giving attention to the site of maximal tenderness was performed using a linear transducer. CT PROTOCOL: Examinations were performed on a MDCT performed using a 4-slice C scanner (TOSHIBA) at 120 kVp and 100 mAs; a pitch of 1 was used. CT of the lower abdomen and pelvis, from the xiphoid to the pubic symphysis, was performed with 80 mL of non-ionic contrast material Iohexol 350 (Omnipaque 350) was injected through a 18-gauge cannula placed in the volar aspect in the cubital vein at a flow rate of 4 ml/s and delay of 50 sec. Axial reconstructions from the raw data were done at 3 mm thick, at 1.5-mm increments were obtained. The second data set was reformatted coronal at a thickness of 3 mm with 3-mm increments .No oral contrast was used. RESULT: From the study it is concluded that CT is more sensitive, specificity, PPV,NPV. Hence, the CT investigation is more accuracy than USG in diagnosing cases of appendicitis. CONCLUSION: Evaluating a case of appendicitis is mainly clinical, depending on the clinical scores and signs. But there is increase in the negative appendectomy rate on depending only on clinical findings. Usually USG is the first primary techniques, considering its easy availability, low cost and reproducible with no radiation But it has its own pitfalls, being operator dependent . CT on the other hand is more specific than USG and hence could rule out appendicitis. Most of the studies including our study has shown that CT has more sensitivity, specificity, Negative predictive value and Positive predictive value in diagnosing appendicitis. Weighing the cost versus the radiation and the real need to rule out appendicitis, and the dire need in search of alternate diagnosis should be considered before deciding over which imaging modality to choose. But CT without doubt has definitely more diagnostic performance than USG in acute appendicitis and our study also proves the same